Treatment of invasive aspergillosis: Polyenes, echinocandins, or azoles?

Combination therapy of murine mucormycosis or aspergillosis with iron chelation, polyenes, and echinocandins.

Liposomal amphotericin B (LAmB) combined wither either micafungin or deferasirox was synergistic in previous murine studies with mucormycosis or aspergillosis. We hypothesized that triple therapy using LAmB, micafungin, and deferasirox could further improve outcomes of mucormycosis or aspergillosis. Triple therapy improved survival and reduced tissue fungal burden of mice with mucormycosis and ...

Caspofungin: the first agent available in the echinocandin class of antifungals.

Caspofungin acetate (Cancidas, MK-0991, L-743,872) is a parenteral antifungal agent indicated in the treatment of invasive aspergillosis in patients who are intolerant of or whose infection is refractory to other antifungal therapies. It is the first member of a novel class of antifungals, the echinocandins, to be made available in the USA. As a class, the echinocandins possess a mechanism of a...

Management of invasive fungal infections: a role for polyenes.

The spectrum of invasive fungal infections (IFIs) continues to evolve with the emergence of rare and resistant fungal pathogens. Clinicians are faced with difficult diagnostic and treatment challenges in the management of immunocompromised patients at high risk of developing IFIs. Early and appropriate antifungal therapy is essential for a successful outcome when treating invasive mycoses. The ...

Azoles in Allergic Bronchopulmonary Aspergillosis.

Chronic necrotizing pulmonary aspergillosis or invasive pulmonary aspergillosis.

Affiliations: Dr. Silvestri is affiliated with Presidio Ospedaliero. Dr. van Saene is affiliated with the University of Liverpool. Dr. de la Cal is affiliated with University Hospital. Dr. De Gaudio is affiliated with the University of Florence. Financial/nonfinancial disclosures: The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizati...